Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

In vitro pharmacokinetics of sirolimus-coated stent for tracheal stenosis

Shanzuan Wang^1,2,4, Zhengxian Chen^1,2,3 , Qunying Lin⁴, Qingyu Lin⁴, Yumei Geng¹, Suwang Wang³

¹Southern Medical University, Guangzhou, Guangdong, 510515; ²Guangdong General Hospital, Guangdong Academy Medical Sciences, Department of Respiratory Medicine, Guangzhou, Guangdong 510000; ³The Sixth Affiliated Hospital Of Sun Yat-sen Univevsity, Department of Respiratory Medicine, Guangzhou, Guangdong 510655; ⁴The Affiliated Hospital of Putian Univevsity, Department of Respiratory Medicine, Putian, Fujian 35110, China.

For correspondence:- Zhengxian Chen Email: zhengxianchen929@sina.com

Received: 24 March 2016 Accepted: 11 April 2017 Published: 31 August 2017

Citation: Wang S, Chen Z, Lin Q, Lin Q, Geng Y, Wang S. In vitro pharmacokinetics of sirolimus-coated stent for tracheal stenosis. Trop J Pharm Res 2017; 16(8):2033-2038 doi: 10.4314/tjpr.v16i8.38

© 2017 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the in vitro pharmacokinetics of sirolimus-coated stent for tracheal stenosis

Methods: Naked nickel titanium alloy stent was placed in methylene chloride leaching solution with different ratios of sirolimus/poly(lactic-co-glycolic acid) (PLGA). The morphology, thickness, and pellicles on the surface of the stent were observed by scanning electronic microscopy. Drug release from the stent was determined by enzyme amplification immunoassay.

Results: Sirolimus was smoothly and uniformly attached to the stent, with an optimal sirolimus: PLGA coating ratio of 1:10. Further increases in sirolimus: PLGA ratio did not improve stent drug loading. A slow release of sirolimus from the stent was observed in the first week, followed by a rapid release and then much slower release process. Release of sirolimus persisted in the stent throughout the period of 42 days.

Conclusion: The sirolimus-coated stent has a good surface morphology, and sustained and effective drug release characteristics. Thus, it may be effective and safe for use in the treatment of tracheal stenosis in vivo.

Keywords: Tracheal stenosis, Sirolimus, Drug-coated stents, poly(lactic-co-glycolic acid) PLGA